Nodular lymphocyte predominant Hodgkin lymphoma with T-cell/histiocyte - rich large B-cell lymphoma pathohistological characteristics and extranodal presentation: Case report and literature review

Nodular lymphocyte predominant Hodgkin lymphoma appears in 5% of lymphoma. Because major biological and clinical differences with classical close relationship to T-cell/histiocyte-rich large B-cell lymphoma, lately the term nodular is accepted. The presence cells preserved phenotype a lack CD30 prerequisite for diagnosis Lymphocyte are typically embedded nodules B lymphocytes (growth patterns A B), but variants that characterized by located outside nodules, Tcell- rich growth pattern T-cell-rich or B-cell-rich diffuse patterns, respectively, have also been described C, D, E, F). Variant associated recurrence progression disease should be recognized specified pathology reports. Broad immunohistochemical panel, including PAX5, CD79a, Bob.1, Oct-2 indicated these cases distinguish between which significant behavior treatment. There different treatment approaches patients depending on pathohistological type, presentation stage disease. Treatment may include active surveillance, radiation therapy, immunotherapy chemotherapy. multidisciplinary approach beneficial optimize management